Polyanionic polymer adjuvants for Haemophilus influenzae B saccharide vaccines

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专利权人:

GLAXOSMITHKLINE BIOLOGICALS S.A.

发明人:

Nathalie Marie-Josephe Garcon,Dominique Lemoine,Florence Emilie Jeanne Francoise Wauters

申请号：

US14509448

公开号：

US09364533B2

申请日:

2014.10.08

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The present invention relates to methods of reducing flocculation in an immunogenic composition, where said immunogenic composition comprises (a) Haemophilus influenzae B capsular polysaccharide or oligosaccharide (PRP) and (b) at least one non-PRP antigen. The invention further relates to kits comprising (i) a first composition comprising a Haemophilus influenzae B capsular polysaccharide or oligosaccharide (PRP) and a polyanionic polymer, and (ii) a second composition comprising a non-PRP antigen adsorbed onto an adjuvant with a zero point charge greater than 8.

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