A technique is provided for performing a computer aided detection (CAD) analysis of a three-dimensional volume using a computer assisted detection and/or diagnosis (CAD) algorithms. The technique includes selecting one or more three-dimensional points of interest in a three-dimensional volume, forward projecting the one or more three-dimensional points of interest to determine a corresponding set of projection points within one or more two-dimensional projection images, and computing output values at the one or more three-dimensional points of interest based on one or more feature values or a CAD output at the corresponding set of projection points.