PROBLEM TO BE SOLVED: To provide a stable topical gel composition useful in the treatment of viral wart infections of the skin, genitals, and eyes, Acari infections and bacterial infections. A topical gel composition comprising 0.1% to 10% povidone-iodine (PVP-I), 30% to 99% dimethyl sulfoxide (DMSO), and 1% to 10% gelling agent. In contrast, the topical gel composition is significantly more effective than a liquid composition containing 0.1% to 10% PVP-I substantially free of gelling agent and 30% to 99% DMSO. A topical gel composition exhibiting properties. [Selection figure] None【課題】皮膚、生殖器、眼のウイルス性いぼ感染、ニキビダニ属感染及び細菌感染の処置において有用である、安定な局所ゲル組成物の提供。【解決手段】0.1%~10%のポビドン-ヨウ素(PVP-I)と、30%~99%のジメチルスルホキシド(DMSO)と、1%~10%のゲル化剤とを含む局所ゲル組成物において、前記局所ゲル組成物は、ゲル化剤を実質的に含まない0.1%~10%のPVP-Iと30%~99%のDMSOとを含む液体組成物に比べて、大きな有効性を示す、局所ゲル組成物。【選択図】なし