The present invention provides PI3K protein kinase modulators, preparation method, the pharmaceutical composition containing the PI3K protein kinase modulators and with PI3K protein kinase modulators treatment, prevent and/or improve the method for kinase mediated disease or illness.本發明提供了PI3K蛋白激酶調節劑、其製備方法、含有所述PI3K蛋白激酶調節劑的藥物組合物和用所述PI3K蛋白激酶調節劑治療、預防和/或改善激酶介導的疾病或病症的方法。