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Novel peptidase dual inhibitors as prodrugs for the treatment of inflammatory and other diseases
专利权人:
イーエムテーエム ゲーエムベーハー
发明人:
アンゾルゲ、 ズィークフリード,ノイベルト、 クラウス,バンク、 ウテ,ライヒシュタイン、 イレーネ,ファウスト、 ユルゲン,タガー、 ミヒャエル,フックス、 ペトラ,ゼンス、 ビアンカ
申请号:
JP2008540493
公开号:
JP5300485B2
申请日:
2006.11.10
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
Compounds of the general formulae (1) and (2) A-B-D-B'-A'(1) and A-B-D-E(2) in which A and A' may be identical or different and are the residue in which X is S, O, CH2, CH2CH2, CH2O or CH2NH, and Y is H or CN, and * designates a chiral carbon atom preferably in S- or L-configuration; B and B' may be identical or different and are an O, N or S containing or non-containing, unsubstituted or substituted, unbranched or branched alkylene residue, cycloalkylene residue, aralkylene residue, heterocycloalkylene residue, heteroarylalkylene residue, arylamidoalkylene residue, heteroarylamidoalkylene residue, unsubstituted or mono- or poly-substituted arylene residue or heteroarylene residue having one or more five-, six- or seven-membered ring(s); D is -S-S- or -Se-Se-; and E is the group -CH2-CH(NH2)-R9 or -CH2-*CH(NH2)-R9 respectively in which R9 is an O, N or S containing or non-containing, unsubstituted or substituted, unbranched or branched alkyl residue, cycloalkyl residue, aralkyl residue, heterocycloalkyl residue, heteroarylalkyl residue, arylamidoalkyl residue, heteroarylamidoalkyl residue, unsubstituted or mono- or poly-substituted aryl residue or heteroaryl residue having one or more five-, six- or seven-membered ring(s) and * designates a chiral carbon atom preferably in the S- or L-configuration; or the acid addition salts thereof with organic and/or inorganic acids; as well as to the use of the compounds of the general formulae (1) and (2) in medicine.
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