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УСОВЕРШЕНСТВОВАННЫЕ ИММОБИЛИЗОВАННЫЕ БИОЛОГИЧЕСКИЕ ОБЪЕКТЫ
专利权人:
ГОР ЭНТЕРПРАЙЗ ХОЛДИНГС; ИНК. (US)
发明人:
ЛЕОНТЕИН Карин (SE),АНТОНИ Пер (SE),НЮСТРОМ Даниель (SE),БЕГОВАЧ Пол (US),ПЕТШАК Кшиштоф (US)
申请号:
RU2013145487/15
公开号:
RU2013145487A
申请日:
2012.03.09
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A device having a surface comprising a layered coating, wherein the outer coating layer comprises a plurality of cationic molecules hyperbranched polymer characterized by (i) the presence of central fragment with a molecular weight of 14-1,000 Yes, (ii) the total molecular weight of 1,500-1,000,000 Yes ( iii) the ratio of the total molecular weight to number molecular weight of the central fragment of at least 80: 1 and (iv) the presence of terminal functional groups, wherein one or more of the terminal functional groups are covalently bonded to obektom.2 anticoagulant. The apparatus of claim 1, wherein the anticoagulant is heparin komponenty.3 objects. The apparatus according to claim 2, wherein the heparin component of the heparin components are full length (native heparin) .4. The apparatus according to claim 2, wherein the heparin is heparin components components depolymerised under the action of nitrous kisloty.5. An apparatus according to any one of claims 1-4, wherein the component is attached to the heparin molecules hyperbranched polymer in any one tochke.6. An apparatus according to any one of claims 1-4, wherein the components of the heparin molecules attached to a hyperbranched polymer through reducing ends komponentov.7 heparin. An apparatus according to any one of claims 1-4, wherein the hyperbranched polymer is selected from poliamidoaminovyh, polipropileniminovyh, polyamine and polyethyleneimine polymers and copolymers containing one or more poliamidoaminovyh, polipropileniminovyh, polyethyleneimine and the hyperbranched polyamic polimerov.8. The apparatus of claim 7, wherein the hyperbranched polymer is a polyamidoamine.1. Устройство, имеющее поверхность, содержащую слоистое покрытие, в котором внешний слой покрытия включает множество молекул катионного сверхразветвленного полимера, характеризующихся (i) наличием центрального фрагмента с молекулярной массой 14-1,000 Да, (ii) общей молекулярной массой 1,500-1,000,000 Да, (iii) отношением общей мол
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