A method for the treatment or prevention of a cardiovascular event in a subject with atherosclerotic vascular disease comprising the step of: b) administering a therapeutically effective amount of a compound of formula (I), a known colchicine derivative and/or a salt thereof R wherein: R1, R2, R3, R4, R9, R10, R11 and R12 independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, halogen, C1-4 haloalkyl, nitro, amino, C2-4 acylamino, C1-4 alkyl or dialkylamino, hydroxyl, C1-4alkoxy, C1-4 alkylthio, a group of the formula - SO2N(Rx)2 or SO2Rx where Rx is C1-4 alkyl,C1-4 acyloxy, or optionally substituted phenyl, optionally substituted phenoxy； R7 and R8 independently represent hydrogen, C1-4 alkyl or C1-4 acyl； and R5', R5 ", R6' and R6" independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, halogen, C1-4 haloalkyl, nitro, amino, C2-4 acylamino, hydroxyl, C1-4 alkoxy or C1-4 alkylthio a group of the formula -SO2N(Rx)2 or SO2Rx where Rx is C1-4 alkyl, C1-4 acyloxy, or optionally substituted phenyl.Un método de tratamiento o prevención de un evento cardiovascular en un sujeto con enfermedad vascular ateroesclerótica que comprende los pasos de: b) administrar una cantidad terapéuticamente efectiva de un compuesto de la fórmula (I), un derivado de colchicina conocido y/o una sal del mismo (ver Fórmula) en la cual: R1, R2, R3, R4, R9, R10, R11 y R12 representan independientemente hidrógeno, C1-4 alquilo, C2-4 alquenilo, C3-6 cicloalquilo, halógeno, C1-4 haloalquilo, nitro, amino, C2-4 acilamino, C1-4 alquilo o dialquilamino, hidroxilo, C1-4 alcoxi, C1-4 alquiltio, un grupo de la fórmula - SO2N(Rx)2 o SO2RX donde Rx es C1-4 alquilo, C1-4 aciloxi, o fenilo opcionalmente sustituido, fenoxi opcionalmente sustituido； R7 y R8 representan independientemente hidrógeno, C1-4 alquilo o C1-4 acilo； y R5', R5'', R6' y R6'' representan independientemente hidrógeno, C1-4 alquilo, C2-4 alquenilo, C3-6 cicloalquilo, halógeno, C1-4 haloalquilo, nitr
