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High-molecular weight conjugate of podophyllotoxins
专利权人:
Masayuki Kitagawa
发明人:
Masayuki Kitagawa,Keizou Ishikawa,Keiichirou Yamamoto,Kazutoshi Takashio,Masao Shibata
申请号:
US12226962
公开号:
US08940332B2
申请日:
2007.05.16
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A novel podophyllotoxin derivative, which is capable of releasing a drug without depending on biological enzymes and can be expected to have an effective therapeutic effect and is soluble in water has been demanded. A polymer having a polyethyleneglycol structural unit and two or more succinic monoamide structural units, particularly a polymer conjugate of a podophyllotoxin in which a carboxylic acid group of polyethyleneglycol/polyaspartic acid copolymer and a hydroxyl group of podophyllotoxin and linked via an ester bond is provided.
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中国工程科技知识中心
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