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Polymer derivatives of nucleic acid antimetabolites
专利权人:
日本化薬株式会社
发明人:
山本 啓一朗,高塩 一俊
申请号:
JP2008543048
公开号:
JP5503872B2
申请日:
2007.11.01
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
[PROBLEMS] A derivative of a nucleic acid antimetabolite is demanded which can show a high therapeutic effect at a low dose. [MEANS FOR SOLVING PROBLEMS] Disclosed is a high molecular weight derivative of a nucleic acid antimetabolite, which is characterized by comprising a high molecular weight compound comprising a polyethylene glycol moiety and a polymer moiety having a carboxyl group in a side chain and a nucleoside derivative which can act as a nucleic acid antimetabolite, wherein the carboxyl group in the side chain is bound to a hydroxyl group in the nucleoside derivative via an ester bond. Also disclosed is a method for producing the high molecular weight derivative.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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