GUILLEMONT, Jérôme Emile Georges,LANSOIS, David Francis Alain,DORANGE, Ismet,ANDRIES, Koenraad Jozef Lodewijk Marcel,KOUL, Anil
申请号：
ES07847811
公开号：
ES2573689T3
申请日:
2007.12.04
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (Ia) or (Ib) ** Formula ** including any stereochemically isomeric form thereof, wherein q is an integer equal to zero, 1, 2, 3 or 4； p is an integer equal to 1, 2, 3 or 4； R1 is alkenyl, alkynyl, -C>； = N-OR11, amino, mono- or di (alkyl) amino, aminoalkyl, mono- or di (alkyl) aminoalkyl, alkylcarbonylaminoalkyl, aminocarbonyl, mono- or di (alkyl) aminocarbonyl, arylcarbonyl , R5aR4aNalkyl, R5aR4aN-, R5aR4aN-C (>； = O) -； R2 is hydrogen, alkyloxy, aryl, aryloxy, hydroxy, mercapto, alkyloxyalkyloxy, alkylthio, mono- or di (alkyl) amino, pyrrolidino or a radical of formula ** Formula ** wherein Y is CH2, O, S, NH or N-alkyl； R3 is alkyl, arylalkyl, aryl-O-alkyl, aryl-alkyl-O-alkyl, aryl, Het, Het-alkyl, Het-O-alkyl, Het-alkyl-O alkyl or ** Formula ** R4 and R5, each independently, are hydrogen, alkyl or benzyl； or R4 and R5, together and including the N to which they are attached, can form a radical selected from the group of pyrrolidinyl, 2-pyrrolinyl, 3-pyrrolinyl, pyrrolyl, imidazolidinyl, pyrazolidinyl, 2-imidazolinyl, 2-pyrazolinyl, imidazolyl, pyrazolyl , triazolyl, piperidinyl, pyridinyl, piperazinyl, imidazolidinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, morpholinyl and thiomorpholinyl, each radical being optionally substituted with alkyl, halo, haloalkyl, hydroxy, alkyloxy, amino, mono- or dialkylamino, alkyl, alkyl alkylthioalkyl and pyrimidinyl； R4a and R5a, together with the nitrogen atom to which they are attached, form a radical selected from the group consisting of pyrrolidino, piperidino, piperazino, morpholino, 4-thiomorpholino, 2,3-dihydroisoindole-1-yl, thiazolidin-3-yl , 1,2,3,6-tetrahydropyridyl, hexahydro-1H-azepinyl, hexahydro-1H-1,4-diazepinyl, hexahydro-1,4-oxazepinyl, 1,2,3,4-tetrahydroisoquinolin-2-yl, pyrrolinyl , pyrrolyl, imidazolidinyl, pyrazolidinyl, 2-imidazolinyl, 2- pyrazolinyl, imidazolyl, pyrazolyl, triazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl and triazinyl, each radical being optiona
