What is disclosed is a system and method for performing a medical diagnosis for a subject of interest using a RGB video camera and a spot radiometer in a non-contact, remote sensing environment. In one embodiment, video images are captured using a RGB video camera in real-time of a subject of interest for medical diagnostic purposes. The video images are analyzed to identify a region of exposed skin for which measurements are desired to be obtained. A relative position of a spot radiometer is then adjusted such that the spot radiometer can measure incident radiation at a desired wavelength range from the identified region of exposed skin. The measurements are then used to perform a medical diagnosis for the subject. Various embodiments are disclosed.