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Rapamycin 40-O-Cyclic Hydrocarbon Esters, Compositions and Methods
专利权人:
BIOTRONIK AG
发明人:
Ronald E. Betts,John Dang Nguyen,Beatris Flores
申请号:
US16359187
公开号:
US20190290810A1
申请日:
2019.03.20
申请国别(地区):
US
年份:
2019
代理人:
摘要:
A new class of rapamycin 40-O-cyclic hydrocarbon esters is disclosed. The 40-O position of the rapamycin ester has the form 40-O—;R, where R is C(O)—;(CH2)n—;X, n is 0, 1 or 2, and X is a cyclic hydrocarbon having 3-8 carbons, optionally containing one or more unsaturated bonds, and one or more linear (CH2)n) and/or cyclic (X) carbon atoms may have an OH or halide group. Also disclosed are therapeutic compositions and methods that employ the novel analogs.
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