40-O-PODSTAWIONA POCHODNA ESTROWA RAPAMYCYNY I WĘGLOWODORU CYKLICZNEGO, KOMPOZYCJE I METODY

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专利权人:

Biotronik AG

发明人:

BETTS, RONALD E.,NGUYEN, JOHN DANG

申请号：

PL13727586

公开号：

PL2859001T3

申请日:

2013.06.03

申请国别(地区):

PL

年份:

2016

代理人:

摘要：

A new class of rapamycin 40-O-cyclic hydrocarbon esters is disclosed. The 40-O position of the rapamycin ester has the form 40-O—R, where R is C(O)—(CH2)n-X, n is 0, 1 or 2, and X is a cyclic hydrocarbon having 3-8 carbons, optionally containing one or more unsaturated bonds, and one or more linear (CH2)n) and/or cyclic (X) carbon atoms may have an OH or halide group. Also disclosed are therapeutic compositions and methods that employ the novel analogs.

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