The invention relates to the fields of medicines, chemistry, and food products, and specifically relates to a rolling mold combination device, a method using a rolling mold to prepare a freeze-dried excipient, and a product thereof. The method of preparing a freeze-dried excipient has the advantage of being able to engrave any character or pattern at any part of a mold, and correspondingly, can produce the character or pattern at any part of a manufactured product, including a product name or trademark, and such an effect cannot be obtained in existing freeze-dried excipient products. The manufactured product can be designed to be any shape and does not readily break inside packaging, reducing loss of medicines and enabling accurate dosages thereof. The method of preparing a freeze-dried excipient adopts mold-release freeze-drying, and a mold does not re-enter a freeze-drying step, improving production efficiency, decreasing production cost, saving energy and protecting the environment. The mold used in the method can perform continuous production, greatly improving production efficiency, the mold has a long service life, further decreasing production costs, saving energy and protecting the environment.
