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DÉRIVÉS DE PYRAZINE FUSIONNÉS UTILES EN TANT QUE STIMULATEURS DE GUANYLATE CYCLASE SOLUBLE
专利权人:
Merck Sharp & Dohme Corp.
发明人:
WHITEHEAD, Alan,ORNOSKI, Olga,RAGHAVAN, Subharekha,BERGER, Raphaelle,GARFUNKLE, Joie,YANG, Zhiqiang,JI, Gang,JIANG, Falong,FU, Jianmin
申请号:
EP17799895
公开号:
EP3458066A4
申请日:
2017.05.11
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
The invention provides certain fused pyrazine compounds of the Formula (I) or a pharmaceutically acceptable salts thereof, wherein X, Y, R1, R3, R4a, R5a, R5b, R6, and the subscript t are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate ("cGMP"), and are generally suitable for the therapy and prophylaxis of diseases or disorders which are associated with a disturbed cGMP balance. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and disorders and for preparing pharmaceuticals for this purpose.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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