DE GROOT, Herbert,MAYER, Christian,PETRAT, Frank,KIRSCH, Michael
申请号：
ES09777024
公开号：
ES2649364T3
申请日:
2009.07.08
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Dispersion of artificial oxygen carriers, especially as a blood substitute, preferably for transfusion purposes, wherein the dispersion contains capsules with reversible oxygen storage capacity, where the capsules comprise an oxygen permeable capsule material, containing and / or including fluorinated, especially perfluorinated, hydrocarbons, preferably perfluorocarbons, wherein the oxygen-permeable capsule material comprises or is composed of an organic oxygen-permeable polymer, wherein the polymer is selected from the group of poly ( lactides-co-glycolides) and polyalkyl cyanoacrylates, as well as their mixtures, where the organic polymer is formed free of sulfide bridges and has a coherent structure, where in capsules the weight ratio of capsule material permeable to oxygen to fluorinated hydrocarbons is in the range of 75: 25 to 10: 90, where the hydrocarbons Fluorinated s have molecular weights in the range of 250 to 2,000 g / mol and are formed in liquid form, where the capsules have a diameter in the range of 50 to 1,000 nm, where the dispersion contains the capsules in amounts related to the volume from 1 to 70% by volume, with respect to the dispersion, where the dispersion adjusts to a physiological pH value and has a specific viscosity η in the range of 0.1 to 1.8 s, with respect to temperatures in the range of 10 ° C to 40 ° C, and where the dispersion is an aqueous-based dispersion and / or contains water as a continuous phase in the form of a physiological and / or isotonic sodium chloride solution, where the dispersion is storage stable.Dispersión de portadores de oxígeno artificiales, en especial como sustituto de la sangre, con preferencia, con fines de transfusión, en donde la dispersión contiene cápsulas con capacidad reversible de almacenamiento de oxígeno, en donde las cápsulas comprenden un material de cápsula permeable al oxígeno, que contiene y/o incluye hidrocarburos fluorados, en especial perfluorados, con preferencia, perfluorocarbonos, en
