Fabrice LE GALL,Sergey KIPRIYANOV,Melvin LITTLE,Uwe REUSCH
申请号：
US13739736
公开号：
US20130115213A1
申请日:
2013.01.11
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Described are mono- and multivalent scFv-antibodies comprising the binding sites specific for the human T cell marker CD3. These antibodies are strongly immunosuppressive and do not cause a significant release of cytokines. Furthermore, polynucleotides encoding said antibodies are described as well as vectors comprising said polynucleotides, host cells transformed therewith and their use in the production of said antibodies. Pharmaceutical compositions containing any of the above mentioned polynucleotides, antibodies or vectors are useful for immunotherapy, preferably against acute transplant rejections.
