David S. F. Young,Helen P. Findlay,Susan E. Hahn,Lisa A. Popp
申请号：
US13211090
公开号：
US08277803B2
申请日:
2011.08.16
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, cytokines, interferons, target or reporter moieties and hematogenous cells.
