An optical coherence tomography system and method with integrated pressure measurement. In one embodiment the system includes an interferometer including: a wavelength swept laser； a source arm in communication with the wavelength swept laser； a reference arm in communication with a reference reflector； a first photodetector having a signal output； a detector arm in communication with the first photodetector, a probe interface； a sample arm in communication with a first optical connector of the probe interface； an acquisition and display system comprising: an A/D converter having a signal input in communication with the first photodetector signal output and a signal output； a processor system in communication with the A/D converter signal output； and a display in communication with the processor system； and a probe comprising a pressure sensor and configured for connection to the first optical connector of the probe interface, wherein the pressure transducer comprises an optical pressure transducer.
