Provided are a p16 variant, polynucleotide for encoding the p16 variant, a method for manufacturing the p16 variant, and a composition containing the p16 variant as an active ingredient to prevent and/or treat cancer. The p16 variant is a p16 protein variant wherein one or more selected from a group consisting of hydrophobic amino acid residues exposed to the outside of the tertiary structure of the protein p16 are substituted by hydrophilic amino acid.COPYRIGHT KIPO 2015p16 변이체, 상기 p16 변이체를 암호화하는 폴리뉴클레오타이드, 상기 p16 변이체의 제조 방법, 및 상기 p16 변이체를 유효성분으로 포함하는 암의 예방 및/또는 치료용 약학 조성물이 제공된다.
