SHAUGHNESSY, John, D., Jr.;BARLOGIE, Barthel;BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
发明人:
SHAUGHNESSY, John, D., Jr.,BARLOGIE, Barthel
申请号：
USUS2011/001020
公开号：
WO2011/152884A9
申请日:
2011.06.06
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides methods for diagnosing and treating multiple myeloma and its high risk subtypes and differentiating between an early failure and a sustained control high risk subtype by measuring expression levels of a subset of 14 genes. The genes MEIS1, SPIB, RNF43, SHISA, SLC43A3, PLK1, RUNX2, or PMAIP1 in the subset are overexpressed in multiple myeloma where overexpression of SHISA is indicative of the early failure high risk subtype. The genes C20orf142, TP53INP, ST6GAL1, 235659_at, YIPF6, or MAN2A1 in the subset are underexpressed in multiple myeloma where underexpression of TP53INP is indicative of the sustained control high risk subtype.
