Compounds with amino amide linkers and pharmaceutical compositions and medicaments comprising such compounds are disclosed. In addition, methods of making such compounds and their uses for treating or ameliorating diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.本發明揭示具有胺基醯胺連接子之化合物及包含此類化合物之醫藥組合物及藥劑。另外,本發明提供製造此類化合物之方法及其用於治療或改善諸如癌症的與蛋白質功能障礙相關聯之疾病、病症或病況之用途。