BLOCAGE DE POINT DE CONTROLE ET INSTABILITE DES MICROSATELLITES

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专利权人:

THE JOHNS HOPKINS UNIVERSITY

发明人:

DIAZ, LUIS,VOGELSTEIN, BERT,KINZLER, KENNETH W.,PAPADOPOULOS, NICKOLAS,LE, DUNG,PARDOLL, DREW M.,TOPALIAN, SUZANNE L.

申请号：

CA2966660

公开号：

CA2966660A1

申请日:

2015.11.12

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

Blockade of immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) shows promise in patients with cancer. Inhibitory antibodies directed at these receptors have been shown to break immune tolerance and promote anti-tumor immunity. These agents work particularly well in patients with a certain category of tumor. Such tumors may be particularly susceptible to treatment because of the multitude of neoantigens which they produce.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/