Checkpoint blockade and microsatellite instability

• 收藏
• 分享

专利权人:

The Johns Hopkins University

发明人:

Diaz, Luis,Vogelstein, Bert,Kinzler, Kenneth W.,Papadopoulos, Nickolas,Le, Dung

申请号：

AU2015346295

公开号：

AU2015346295A1

申请日:

2015.11.12

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

Blockade of immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) shows promise in patients with cancer. Inhibitory antibodies directed at these receptors have been shown to break immune tolerance and promote anti-tumor immunity. These agents work particularly well in patients with a certain category of tumor. Such tumors may be particularly susceptible to treatment because of the multitude of neoantigens which they produce.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/