Jacek Capala,Dale O. Kiesewetter,Gabriela Kramer-Marek,Sang Bong Lee
申请号：
US12528823
公开号：
US08303960B2
申请日:
2008.02.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides a radiolabeled affibody molecule comprising a fragment of an IgG-binding domain of protein A from Staphylococcus aureus, a bifunctional linker, and a radiolabel comprising 18F or 76Br, wherein the bifunctional linker links the fragment and the radiolabel. The affibody molecule binds with high affinity to select receptors, which are over-expressed in certain cancers. Since the radionuclides emit a positron, the in vitro and in vivo binding characteristics of the radiolabeled affibody can be assessed using diagnostic imaging.
