Van Brandt, Sven Franciscus Anna,De Cleyn, Michel Anna Jozef,Fustero Lardies, Santos,Mateu Sanchis, Natalia,Trabanco-Suarez, Andres Avelino,Delgado-Gonzalez, Oscar,Gijsen, Henricus Jacobus Mari
申请号：
AU2015367594
公开号：
AU2015367594A1
申请日:
2015.12.16
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The present invention relates to 2,3,4,5-tetrahydropyridin-6-amine and 3,4- dihydro-2H-pyrrol-5-amine compound inhibitors of beta-secretase having the structure shown in Formula (I), wherein the radicals are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease, dementia associated with beta- amyloid, age-related macular degeneration, type 2 diabetes or metabolic disorders.
