Andrés Avelino Trabanco-Suárez,Óscar Delgado-González,Henricus Jacobus Maria Gijsen,Michiel Luc Maria Van Gool,Sven Franciscus Anna Van Brandt,Michel Anna Jozef De Cleyn,Santos Fustero Lardiés,Natalia
申请号：
US15536474
公开号：
US10106524B2
申请日:
2015.12.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to 2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2H-pyrrol-5-amine compound inhibitors of beta-secretase having the structure shown in Formula (I)wherein the radicals are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimers disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Downs syndrome, dementia associated with stroke, dementia associated with Parkinsons disease, dementia associated with beta-amyloid, age-related macular degeneration, type 2 diabetes or metabolic disorders.
