SOTH, Michael, J.,JONES, Philip,LIU, Gang,LE, Kang,CROSS, Jason
申请号：
CL2019001539
公开号：
CL2019001539A1
申请日:
2019.06.05
申请国别(地区):
CL
年份:
2019
代理人:
摘要：
The compounds contained in this document inhibit the activity of the reticular chain waistband of Diplococcus leucocytes (DLK) (Map3K12).Pharmacopoeia and ampere, Icatel, props and M AMP, Icatel, all diseases treated by DLK, such as neurological and ampere diseases, Oacute, Lesi Amp, Oacute, N traum amp, Aacute, Tica a la central nerve system and neuronas del sistema neuro extra amp, Eacute, Rico For example, Apoplej Amp, IACUTE, A, Lesi Amp, Oacute, N brain traum amp, Aacute, Tica, Lesi Amp, Oacute, N de M Amp, Eacute, Dula Espinal,Or because of neurodegenerative diseases CR AMP； Oacute； Nico (e.g. Alzheimer's disease, anterior and motor dementia, Parkinson's disease, Huntington's disease, Amiotr Amp lateral sclerosis； Oacute； FICA, Espinocerebelar Ataxia, PAR AMP； AACUTE； progressive upper limb disorders)； Levy's Physical Diseases Kennedy's Diseases and Other Related DiseasesNeuropat Amp； IACUTE； As derivas de Da Amp； Ntilde； O Neurol Amp； Oacute； Cico (Neuropat Amp； IACUTE； A External Amp； EACUTE； rich in chemotherapy, Neuropat Amp； IACUTE； EACUTE； TICA and related diseases) and cognitive impairment A.1.1.1.1. Cognitive impairment induced by chemotherapy (TAMBI AMP； EACUTE； N, chemotherapy)； LT； / P GT；<；p>；EN ESTE DOCUMENTO SE DAN A CONOCER COMPUESTOS QUE INHIBEN LA ACTIVIDAD DE CINASA DE LA CINASA DE CREMALLERA DE LEUCINA DUAL (DLK) (MAP3K12), COMPOSICIONES FARMACÉ；UTICAS Y MÉ；TODOS DE TRATAMIENTO DE ENFERMEDADES MEDIADAS POR DLK, TALES COMO ENFERMEDADES NEUROLÓ；GICAS QUE RESULTAN DE LESIÓ；N TRAUMÁ；TICA AL SISTEMA NERVIOSO CENTRAL Y NEURONAS DEL SISTEMA NERVIOSO PERIFÉ；RICO (POR EJEMPLO, APOPLEJÍ；A, LESIÓ；N CEREBRAL TRAUMÁ；TICA, LESIÓ；N DE MÉ；DULA ESPINAL), O QUE RESULTAN DE UN PADECIMIENTO NEURODEGENERATIVO CRÓ；NICO (POR EJEMPLO, ENFERMEDAD DE ALZHEIMER, DEMENCIA FRONTOTEMPORAL, ENFERMEDAD DE PARKINSON, ENFERMEDAD DE HUNTINGTON, ESCLEROSIS LATERAL AMIOTRÓ；FICA, ATAX
