PROCÉDÉ DE CO-CULTURE D'UNE SOUCHE BACTÉRIENNE DE L'ESPÈCE SPHINGOMONAS ET D'UNE SOUCHE DE CHAMPIGNON DE L'ESPÈCE ASPERGILLUS, NOUVELLES GLIONITRINES ANTICANCÉREUSES ET ANTIBIOTIQUES DÉRIVÉES DE CE PROCÉDÉ DE CO-CULTURE, ET COMPOSITION PHARMACEUTIQUE CONTENANT DES GLIONITRINES OU UN DE LEURS SELS PHARMACEUTIQUEMENT ACCEPTABLE COMME INGRÉDIENT ACTIF
YANG, HYUN OK,KWON, HAK CHEOL,PARK, HYUN-BONG,YOO, JI-HYE
申请号：
EP08851184
公开号：
EP2209887A4
申请日:
2008.10.23
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The present invention relates to a co-culture method of Sphingomonas sp. bacterial strain and Aspergillus sp. fungus strain, in which the novel Sphingomonas sp. bacterial strain KMK-001 is cultured in a liquid medium and the novel Aspergillus sp. strain KMC-901 separately cultured in another liquid medium is added to the above culture solution, a novel glionitrin biosynthesized therefrom and a pharmaceutical composition comprising the said glionitrin or its pharmaceutically acceptable salt as an active ingredient. The glionitrin herein has strong cytotoxic effect on cancer cells and has antibiotic effect on 10 pathogenic bacteria including the novel Sphingomonas sp. bacterial strain KMK-001, so that it can be effectively applied in antibiotics or anti-cancer agents.
