SangKon Oh;Jacques F. Banchereau;Gerard Zurawski;Maria Virginia Pascual
发明人:
SangKon Oh,Maria Virginia Pascual,Gerard Zurawski,Jacques F. Banchereau
申请号：
US13397932
公开号：
US20120213768A1
申请日:
2012.02.16
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Biomarkers and therapies against autoimmune diseases, including systemic lupus erythematosus (SLE) are described herein. The present invention is based on the discovery of B cell maturation antigen (BCMA) and BCMA variant expression on SLE monocytes that can be directly associated with disease activity. The findings of the present invention enable the design of monoclonal antibodies or recombinant proteins that can block BCMA and BCMA variants as well as BCMA-bound APRIL.
