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1,2,4,-triazin-3,5-dione compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
专利权人:
Wilfried Braje;Sean Colm Turner;Andreas Haupt;Udo Lange;Hervé Geneste;Karla Drescher;Liliane Unger;Ana Lucia Relo;Anton Bespalov
发明人:
Wilfried Braje,Sean Colm Turner,Andreas Haupt,Udo Lange,Hervé Geneste,Karla Drescher,Liliane Unger,Ana Lucia Relo,Anton Bespalov
申请号:
US12740714
公开号:
US08492540B2
申请日:
2008.10.31
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The invention relates to compounds of the formula I:whereinA is a saturated or unsaturated hydrocarbon chain having a chain length of 4 to 6 carbon atoms, the hydrocarbon chain being unsubstituted or substituted by 1, 2 or 3 methyl groups;R1 is selected from the group consisting of hydrogen, C1-C3 alkyl and fluorinated C1-C3 alkyl;R2 is hydrogen, halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, fluorinated C1-C3 alkyl or fluorinated C1-C3 alkoxy;R3 is selected from the group consisting of branched C4-C6 alkyl and C3-C6 cycloalkyl, andR4 is C1-C6 alkyl, C3-C6 cycloalkyl, fluorinated C1-C3-alkyl and fluorinated C3-C6 cycloalkyl.and the physiologically tolerated salts of these compounds and the N-oxides thereof.The invention also relates to a pharmaceutical composition that comprises at least one compound of the formula I and/or at least one physiologically tolerated acid addition salt thereof, and further to a method for treating disorders that respond beneficially to dopamine D3 receptor antagonists or dopamine D3 agonists, said method comprising administering an effective amount of at least one compound or physiologically tolerated acid addition salt of the formula I to a subject in need thereof.
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