Varian Medical Systems, Inc.;Montefiore Medical Center
发明人:
Chandan Guha,Robert M. Sutherland,Alan Alfieri,Jayanta Roy-Chowdury
申请号：
US15063251
公开号：
US20170035938A1
申请日:
2016.03.07
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed are methods of obtaining an expanded population of mammalian ex vivo cells for treating a mammalian subject by (a) administering to a subject an effective amount of an agent that confers a growth disadvantage to at least a subset of endogenous cells at the site of engraftment； (b) administering to the subject an effective amount of a mitogenic stimulus for the ex vivo cells； and (c) administering the ex vivo cells to the subject, wherein the ex vivo cells engraft at the site and proliferate to a greater extent than the subset of endogenous cells, to repopulate at least a portion of the engraftment site with the ex vivo cells. The repopulated cells can be harvested or left at the engraftment site. Methods of treating brain injury in a subject by engrafting ex vivo cells at the site of injury are also described.
