Svein Kvale,Ingrid Henriksen,Ole Johannes TOKERUD,Per Sontum
申请号：
US15314353
公开号：
US20170258950A1
申请日:
2015.06.26
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to a method for sterilisation of phospholipid suspensions, useful in the preparation of ultrasound contrast agent precursors comprising phospholipid-stabilised perfluorobutane microbubbles. The method provides sterility assurance, without undue thermal degradation of the phospholipid. The method is also amenable to commercial scale manufacture. Also provided are methods of preparing kits and ultrasound contrast agents incorporating the sterilisation method of the invention.
