Ron L. Hale,Craig C. Hodges,Peter M. Lloyd,Amy T. Lu,Daniel J. Myers,Joshua D. Rabinowitz,Martin J. Wensley,Jeffrey A. McKinney,Alejandro C. Zaffaroni
申请号：
US12117737
公开号：
US08235037B2
申请日:
2008.05.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.
