Composition for preventing and treating acetaminophen inducing hepatotoxicity containing TNP(N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine) as an effective ingredient
Korea Advanced Institute of Science and Technology
发明人:
Seyun Kim,Yong-Mahn Han,Young-Ran Kim,Seulgi Lee
申请号：
US15032295
公开号：
US09636343B2
申请日:
2015.07.03
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to a composition for the prevention and treatment of liver toxicity originated from acetaminophen comprising TNP (N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine) as an active ingredient. The present inventors confirmed that TNP known as a 5-inosito pyrophosphate inhibitor suppressed apoptosis caused by acetaminophen in human embryonic stem cell-derived liver cells, mouse liver cells, and human hepatoma cell lines, up-regulated glutathione converted in liver cells, and inhibited JNK phosphorylation that is a kind of response against stress increased by acetaminophen. The inventors further confirmed that TNP had the activity of protecting liver cells from the toxicity caused by acetaminophen in an animal model. Therefore, TNP can be efficiently used as an active ingredient for a composition for the prevention and treatment of liver toxicity caused by acetaminophen.
