JAESCHKE, GEORG,JOLIDON, SYNESE,STADLER, HEINZ,VIEIRA, ERIC,LINDEMANN, LOTHAR,GUBA, WOLFGANG,GREEN, LUKE,RICCI, ANTONIO,RUEHER, DANIEL
申请号：
ECSP12012212
公开号：
ECSP12012212A
申请日:
2012.10.02
申请国别(地区):
EC
年份:
2012
代理人:
摘要：
The present Invention relates to Derivatives of formula I in etinilo； that is: U = N - or C - = (R5)； V - or - ch = CH = N； W = OR = N -； under the condition that only one of U, V or W can be Nitrogen, R5 is Hydrogen, Halogen or Methyl； and N - (r6) -, - O -, - C (R7) (R7) - CH2O -, - or - ch2s (OR) 2； This is Hydrogen or lower alkyl R6 and R7 / R7 'Independence with each other are Hydrogen, Hydroxy,Lower Lower alkyl or alkoxy； r1 is phenyl or heteroaryl, which are optionally substituted by one or two substituents selected from Halogen, Lower and Lower alkoxy alkyl； R2 / R2 'with Independence between is Hydrogen, Lower alkyl, cycloalkyl Hydroxy, alkoxy Lower C3 - C6CH2 or lower alkoxy - along with the carbon Atom to which they are United Can form a cycloalkyl or C3 C6 Ring containing - - the number ch2och2； M is 0, 1 or 2； in the case that m is 1 / R3, R3 'among themselves are independently Hydrogen, Lower alkyl,CH2 or lower alkoxy - along with the carbon Atom to which they are United Can form a cycloalkyl or C3 C6； R3 and R2 together with the carbon Atom to which they are United Can form a C3 6 or cycloalkyl Ring containing - (CH2) - the number 2och2； n is 0 OR 1； in the case that n is 1 / R4, r 4 'with Independence between is Hydrogen, Lower alkyl,CH2 or lower alkoxy - along with the carbon Atom to which they are United Can form a cycloalkyl C3 C6； R4 and R2 together with the carbon Atom to which they are United Can form a cycloalkyl C3 - 6；La presente invención se refiere a derivados de etinilo de la fórmula I； Ien la que:U es =N- o =C(R5)-；V es -CH= o -N=；W es =CH- o =N-；con la condición de que solamente uno de U, V o W pueda ser nitrógeno,R5 es hidrógeno, metilo o halógeno；Y es -N(R6)-, -O-, -C(R7')(R7)-, -CH2O- o -CH2S(O)2-；dicho R6 es hidrógeno o alquilo inferior y R7/R7' con independencia entre sí son hidrógeno, hidroxi, alquilo inferior o alcoxi inferior；R1 es fenilo o heteroarilo, que están opcionalmente sustituidos por uno o dos sustituyentes elegidos
