Cirillo, Agostino,Colloca, Stefano,Ercole, Bruno Bruni,Meola, Annalisa,Nicosia, Alfreda,Sporeno, Elisabetta
申请号：
HUE09176105
公开号：
HUE033576T2
申请日:
2005.01.18
申请国别(地区):
HU
年份:
2017
代理人:
摘要：
The present invention provides recombinant replication-defective adenoviral vectors derived from chimpanzee adenoviruses and methods for generating recombinant adenoviruses in human E1-expressing cell lines. The invention also provides compositions and methods suitable for use for the delivery and expression of transgenes encoding immunogens against which a boosted immune response is desired. The invention further provides methods of generating clinical grade vector stocks suitable for use in humans. In a particular embodiment the invention contemplates the use of vectors comprising transgenes which encode tumor associated antigens in vaccines and pharmaceutical compositions for the prevention and treatment of cancer.
