Gary J. Nabel,Cheng Cheng,Wing-Pui Kong,Jason G.D. Gall,C. Richter King
申请号：
US13568239
公开号：
US20120302627A1
申请日:
2012.08.07
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides a method of inducing an immune response against a human immunodeficiency virus (HIV) in a mammal. The method comprises administering to the mammal an adenoviral vector composition comprising one or more adenoviral vectors encoding two or more different HIV antigens, the production of which induces an immune response against HIV in the mammal. The invention also provides an adenoviral vector composition comprising four adenoviral vectors encoding an HIV clade A Env protein, an HIV clade B Env protein, an HIV clade C Env protein, and a fusion protein comprising an HIV clade B Gag protein and Pol protein, respectively.
