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A brass amide and urea derivative containing isoaromatics, substituted as an adhesive for vanilloide receptor
专利权人:
GRUNENTHAL GMBH
发明人:
FRANK-FOLTYN, ROBERT,BAHRENBERG, GREGOR,CHRISTOPH, THOMAS,LESCH, BERNHARD,LEE, JEEWOO
申请号:
PE2014000105
公开号:
PE20140836A1
申请日:
2012.07.25
申请国别(地区):
PE
年份:
2014
代理人:
摘要:
1. Carbohydrate and urea from formula (I), wherein R1 is h, C (= O) - Oh, NH2, among others; R2 is h, F, CN, CF3; R3 is h or residual alifatic (C1-C10);N is 1-4, R3a is h or alifatic residue (C1-C4);R4A is h, a fatty residue (C1-C4),1.Cyclolimatico(C3-C6),Among other things, it is O, s or n-cn; Z is n or c-r4b, where r4b is h or enoic acid residue (C1-C4);T1 is n or c-r5; U1 is n or c-r6; V is n or c-r7; U2 is n or c-r8; T2 is n or c-r9; R5, R6, R7, R8 and R9 are h, F, NO2, CN, CFH2, etc. The most popular compounds are n - ((1 - (3-chlorophenyl) - 3 - (trifluoromethyl) - 1h-pirazol-5-il) methyl) - 2 - (pyridine-2-il) acetyl; N - ((3-ter-butil-1 - (3-chlorophenyl) - 1h-pirazol-5-il) methyl) - 2 - (pyridine-2-il) propane, etc. He also mentioned a pharmaceutical composer These compounds are ligation of vanilloide receptors for the treatment of pain, Parkinson's disease, irritable bowel sindromeSE REFIERE A COMPUESTOS DERIVADOS DE CARBOXAMIDA Y UREA DE FORMULA (I) DONDE R1 ES H, C(=O)-OH, OH, NH2, ENTRE OTROS; R2 ES H, F, CN, CF3, ENTRE OTROS; R3 ES H O UN RESIDUO ALIFATICO(C1-C10); n ES DE 1 A 4; R3a ES H O UN RESIDUO ALIFATICO(C1-C4); R4a ES H, UN RESIDUO ALIFATICO(C1-C4), CICLOALIFATICO(C3-C6), ENTRE OTROS; Y ES O, S O N-CN; Z ES N O C-R4b, EN DONDE R4b ES H O UN RESIDUO ALIFATICO(C1-C4); T1 ES N O C-R5; U1 ES N O C-R6; V ES N O C-R7; U2 ES N O C-R8; T2 ES N O C-R9; R5, R6, R7, R8 Y R9 SON CADA UNO H, F, NO2, CN, CFH2, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-((1-(3-CLOROFENIL)-3-(TRIFLUOROMETIL)-1H-PIRAZOL-5-IL)METIL)-2-(PIRIDIN-2-IL)ACETAMIDA; N-((3-TER-BUTIL-1-(3-CLOROFENIL)-1H-PIRAZOL-5-IL)METIL)-2-(PIRIDIN-2-IL)PROPANAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON LIGANDOS DEL RECEPTOR VANILLOIDE SIENDO UTILES EN EL TRATAMIENTO DE DOLOR, ENFERMEDAD DE PARKINSON, SINDROME DEL INTESTINO IRRITABLE
来源网站:
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