Refers to a compound of formula I, where M is 0 - 1 a and B are independent and different from each other, hydrogen or a compound of formula II is a nitrogenous heterocycle W n is 1 - 2 r1 is c1-4 alkyl, halogen, alkoxy c1-4, among others R2 is H, halogen, c1-c4 alkyl, among others R5 Is a compound of formula III, R3 and R4 are independently - H, halogen,C1-c4 alkyl, among others. Preferred compounds are: 1 - [4 - (4 - chlorine - 3 - trifluoromethyl phenyl) - 3.6 - dihydro - 2H - pyridin-1-yl] - 2 - [4 - (5 - fluoro - il - 2 - pyrimidin-2-yl) - 3.8 Grabarsky, ITs The Wrong Guy Bicyclo [3.2.1] - il - 3 Oct] ethanone hydrochloride acid, 6 - ((3S, 5R) - 3.5 - 4 - dimethyl - 2 - oxo - [2 - (phenyl 2,4,6,7 - 4.3 - tetrahidropirazolo [c] pyridin - 5 - il) ethyl] piperazin-1-yl } derivates, among others.It also relates to a Pharmaceutical composition. This Compound is an antagonist of the p75 receptor useful in the treatment of overactive bladder.SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE: m ES 0 - 1 A Y B SON, INDEPENDIENTES Y DIFERENTES ENTRE SI, HIDROGENO O UN COMPUESTO DE FORMULA II W ES UN HETEROCICLICO NITROGENADO n ES 1-2 R1 ES HALOGENO, ALQUILO C1-4, ALCOXI C1-4, ENTRE OTROS R2 ES H, HALOGENO, ALQUILO C1-C4, ENTRE OTROS R5 ES UN COMPUESTO DE FORMULA III, DONDE R3 Y R4 SON, INDEPENDIENTEMENTE ENTRE SI, H, HALOGENO, ALQUILO C1-C4, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-[4-(4-CLORO-3-TRIFLUOROMETIL-FENIL)-3,6-DIHIDRO-2H-PIRIDIN-1-IL]-2-[8-(5-FLUORO-PIRIMIDIN-2-IL)-3,8-DIAZA-BICICLO[3.2.1]OCT-3-IL]-ETANONA HIDROCLORURO DEL ACIDO 6-{(3S,5R)-3,5-DIMETIL-4-[2-OXO-2-(2-FENIL-2,4,6,7-TETRAHIDROPIRAZOLO[4,3-C]PIRIDIN-5-IL)ETIL]PIPERAZIN-1-IL}NICOTINICO ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN ANTAGONISTA DEL RECEPTOR P75, UTIL EN EL TRATAMIENTO DE VEJIGA SOBREACTIVA.
