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Anti A beta antibody formulation
专利权人:
Angela Kantor;Donna Luisi;Nicholas W. Warne
发明人:
Nicholas W. Warne,Donna Luisi,Angela Kantor
申请号:
US12637508
公开号:
US08318164B2
申请日:
2009.12.14
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides formulations for maintaining the stability of Aβ binding polypeptides, for example, Aβ antibodies. Exemplary formulations include a tonicity agent such as mannitol and a buffering agent or amino acid such as histidine. Other exemplary formulations include an antioxidant in a sufficient amount as to inhibit by-product formation, for example, the formation of high molecular weight polypeptide aggregates, low molecular weight polypeptide degradation fragments, and mixtures thereof. The formulations of the invention optionally comprise a tonicity agent, such as mannitol, and a buffering agent or amino acid such as histidine. The formulations are suitable for several different routes of administration.
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