FLOHR, ALEXANDER,GALLEY, GUIDO,JAKOB-ROETNE, ROLAND,KITAS, ERIC ARGIRIOS,PETERS, JENS-UWE,WOSTL, WOLFGANG
申请号：
ES04787028
公开号：
ES2548720T3
申请日:
2004.09.27
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Compounds of general formula I ** Formula ** wherein R 1 is - (CHR ') q-aryl or - (CHR') q-heteroaryl, which are unsubstituted or mono, di- or tri-substituted by lower alkyl, alkoxy lower, CF3 or halogen, or is lower alkyl, lower alkenyl, - (CH2) n-Si (CH3) 3, - (CH2) nO-lower alkyl, - (CH2) nS-lower alkyl, - (CH2) q- cycloalkyl, - (CH2) n- [CH (OH)] m- (CF2) p-CHqF (3-q), or is - (CH2) n-CR2-CF3, where the two radicals R form together with the carbon atom a cycloalkyl ring； R 'is hydrogen or lower alkyl； n is 1, 2 or 3； m is 0 or 1； p is 0, 1, 2, 3, 4, 5 or 6； q is 0, 1, 2 or 3； R2 is hydrogen or lower alkyl； R3 is hydrogen, lower alkyl, -CH2CF2CF3, CH2CF3, (CH2) 2CF3, CF3, CHF2, CH2F or is aryl, optionally mono, di or tri-substituted by halogen, or is - (CH2) nNR5R6, where R5 and R6 they are independently of each other hydrogen or lower alkyl； R4 is one of the following groups 20 a) or b) wherein R7 is hydrogen, lower alkyl, - (CH2) n-CF3 or - (CH2) n-cycloalkyl； R8 is hydrogen, lower alkyl, -C (O) -phenyl, -C (O) -alkyl, -C (O) O- (CH2) n-cycloalkyl, -C (O) O- (CH2) n- lower alkyl, -C (O) NH- (CH2) n-lower alkyl or -C (O) NH- (CH2) n-cycloalkyl； R9 is hydrogen, lower alkyl, - (CH2) n-cycloalkyl or - (CH2) n-CF3； wherein the term "lower" in "lower alkyl" or "lower alkoxy" means that the group contains 1 to 10 carbon atoms and the term "lower" in lower alkenyl "means that the group contains 2 to 10 atoms of carbon； and pharmaceutically acceptable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof.Compuestos de fórmula general I**Fórmula** en donde R1 es -(CHR')q-arilo o -(CHR')q-heteroarilo, que están sin sustituir o mono, di- o tri-sustituidos por alquilo inferior, alcoxilo inferior, CF3 o halógeno, o es alquilo inferior, alquenilo inferior, -(CH2)n-Si(CH3)3, -(CH2)n-O-alquilo inferior, -(CH2)n-S-alquilo inferior, -(CH2)q-cicloalquilo, -(CH2)n-[CH(OH)]m-(CF2)p-CHqF(3-q), o es -(CH2)n-CR2- CF3, en donde los dos radicales R
