National Research Council of Canada;YM Biosciences Inc.
发明人:
Tikhomirov, Ilia Alexandre,Jaramillo, Maria L.,O'Connor-McCourt, Maureen D.,Sulea, Traian,Gilbert, Renald,Gaillet, Bruno,Baardsnes, Jason,Banville, Myriam,Grothe, Suzanne,OConnor-McCourt, Maureen D.
申请号：
AU2012211014
公开号：
AU2012211014A1
申请日:
2012.01.20
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
Herein described are antibodies to epidermal growth factor receptor (EGFR) having an EGFR binding affinity that is sufficient to kill disease cells presenting EGFR at high density, but is insufficient for binding to normal cells. A therapeutic effect is thus achieved while avoiding adverse events that result from unintended binding to normal cells.
