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ANTIBODIES SELECTIVE FOR CELLS PRESENTING EGFR AT HIGH DENSITY
专利权人:
发明人:
TIKHOMIROV ILIA ALEXANDRE,JARAMILLO MARIA L,OCONNOR MCCOURT Maureen D,SULEA TRAIAN,GILBERT RENALD,GAILLET BRUNO,BAARDSNES JASON,BANVILLE MYRIAM,GROTHE SUZANNE
申请号:
IN1411/MUMNP/2013
公开号:
IN2013MN01411A
申请日:
2013.07.22
申请国别(地区):
IN
年份:
2014
代理人:
摘要:
Herein described are antibodies to epidermal growth factor receptor (EGFR) having an EGFR binding affinity that is sufficient to kill disease cells presenting EGFR at high density but is insufficient for binding to normal cells. A therapeutic effect is thus achieved while avoiding adverse events that result from unintended binding to normal cells.
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