The present invention relates to: a composition for inhibiting vascular calcification, containing a dipeptidyl peptidase-4 (DPP-4) inhibitor as an active ingredient a composition, containing DPP-4, for screening for inhibitors of vascular calcification and a method for screening for inhibitors of vascular calcification by using the same. According to the present invention, the DPP-4 inhibitor can effectively inhibit vascular calcification, and thus can be applied as a therapeutic agent capable of preventing or treating various adult diseases such as cardiovascular disease, renal disease, and aging, which are related to vascular calcification, and the DPP-4 protein and gene can be effectively used for screening in the development of novel drugs for inhibiting vascular calcification.La présente invention concerne : une composition destinée à inhiber la calcification vasculaire, contenant un inhibiteur de la dipeptidyl peptidase-4 (DPP-4) en tant que principe actif une composition contenant de la DPP-4, destinée au criblage dinhibiteurs de la calcification vasculaire et une méthode de criblage dinhibiteurs de la calcification vasculaire lutilisant. Selon la présente invention, linhibiteur de la DPP-4 peut efficacement inhiber la calcification vasculaire, et peut donc être utilisé comme agent thérapeutique capable de prévenir ou de traiter diverses maladies de ladulte liées à la calcification vasculaire, telles que des maladies cardio-vasculaires, des affections rénales et le vieillissement, et la protéine et le gène DPP-4 peuvent être efficacement utilisés pour le criblage lors du développement de nouveaux médicaments pour linhibition de la calcification vasculaire.본 발명은 DPP-4(dipeptidyl peptidase-4) 저해제를 유효 성분으로 함유하는 혈관 석회화(Vascular calcification) 억제용 조성물, DPP-4를 포함하는 혈관 석회화 억제제 스크리닝용 조성물 및 이를 이용한 혈관 석화화 억제제의 스크리닝 방법에 관한 것이다. 본 발명에 따르면, DPP-4 저해제는 혈관 석회화를 효과적으로 억제할 수 있으므로 이를 혈관 석회화와 관련된 심혈관 질환, 신장 질환 및 노화 등의 각종 성인병을 예방 또는 치료할 수 있는 치료제로서 적용할 수 있으며, DPP-4 단백질과 유전자는 혈관
