РАУ Харальд (DE),КНАППЕ Томас (DE),ЛАУФЕР Буркхардт (DE),РАЙМАНН Роми (DE),ВАЙСБРОД Замюэль (DE),СПРОГЕ Кеннетт (US),БИЗЕК Никола (DE),ШТАРК Зебастиан (DE),ФОЙГТ Тобиас (DE)
申请号：
RU2015117536
公开号：
RU2015117536A
申请日:
2013.10.08
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A pharmaceutical composition for the treatment of one or more ophthalmic diseases, comprising one or more pharmaceutically acceptable excipients and VEGF-neutralizing prodrug, wherein the prodrug comprises a covalently bound VEGF-neutralizing biologically active sostavlyayuschuyu.2. A pharmaceutical composition according to claim. 1, characterized in that the VEGF-neutralizing prodrug is a prodrug associated with nositelem.3. A pharmaceutical composition according to claim. 2, characterized in that in the prodrug carrier associated with the carrier is gidrogel.4. A pharmaceutical composition according to claim. 2 or 3, characterized in that the carrier is a hydrogel based PEG.5. A pharmaceutical composition according to claim. 1, characterized in that the treatment comprises intraocular administering prolekarstva.6. A pharmaceutical composition according to claim. 5, characterized in that the intraocular administration of the prodrug is accomplished by the intraocular inektsii.7. A pharmaceutical composition according to Claim. 1 or 2, characterized in that the prodrug is contained in a pharmaceutical composition has a concentration of from 5 to 200 mg of prodrug / mL of the pharmaceutical kompozitsii.8. A pharmaceutical composition according to Claim. 1 or 2, characterized in that the composition comprises from 8 to 80 percent by weight of VEGF-neutralizing biologically active component based on the total weight prolekarstva.9. A pharmaceutical composition according to claim. 6, characterized in that the injection is carried out in a volume of injection in the range from 10 to 200 l inektsiyu.10. A pharmaceutical composition according to claim. 5 or 6, characterized in that the time period between two intraocular injections VEGF-neutralizing prodrug is at least 1 mesyats.11.1. Фармацевтическая композиция для лечения одного или более офтальмологических заболеваний, содержащая один или более фармацевтически приемлемых эксципиентов и VEGF-нейтрализующее пролекарств
