Christian Hubschwerlen,Hans Locher,Philippe Panchaud,Jean-Luc Specklin
申请号：
US12463281
公开号：
US08124623B2
申请日:
2009.05.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to novel chimeric antibiotics of formula IwhereinR1 represents OH, OPO3H2 or OCOR5R2 represents H, OH or OPO3H2A represents N or CR6R3 represents H or fluorineR4 is H, (C1-C3) alkyl, or cycloalkylR5 is the residue of a naturally occurring amino acid, of the enantiomer of a naturally occurring amino acid or of dimethylaminoglycineR6 represents H, alkoxy or halogen andn is 0 or 1and to salts (in particular pharmaceutically acceptable salts) of compounds of formula I.These chimeric compounds are useful in the manufacture of medicaments for the treatment of infections (e.g. bacterial infections).
