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METHOD OF BORON NITRIDE NANOPARTICLE FABRICATION FOR ANTITUMOR DRUG DELIVERY
专利权人:
NATIONAL UNIVERSITY OF SCIENCE AND TECHNOLOGY "MISiS"
发明人:
SHTANSKY, Dmitry Vladimirovich,KOVALSKII, Andrey Mikhailovich,MATVEEV, Andrei Trofimovich,SUKHORUKOVA, Irina Viktorovna,GLOUSHANKOVA, Natalia Aleksandrovna,ZHITNYAK, Irina Yur,evna
申请号:
RURU2015/000064
公开号:
WO2016/080860A8
申请日:
2015.02.04
申请国别(地区):
WO
年份:
2017
代理人:
摘要:
Field of the Invention. This invention relates to nanomedical technologies, namely to the fabrication of nanocarriers of drugs for antitumor chemotherapy. Disclosure of the Invention. The technical result of the invention consists of increasing the efficiency of antitumor chemotherapy by increasing the activity of the cell absorption of nanocontainers loaded with an antitumor drug, avoiding of the nanocontainer toxicity for cells due to the use of dispersed boron nitride nanoparticles of 50-300 nm in diameter with a well-developed outer surface. Technical result is achieved as follows. The method of boron nitride nanoparticles fabrication for antitumor drug delivery to tumor cells includes synthesis of spherical boron nitride nanoparticles of 50-300 nm in diameter with a well-developed outer surface by chemical vapor deposition using ammonia reaction gas, argon transport gas and powder mixture composed of amorphous boron and oxidizing reactants. Chemical deposition is carried out under the following conditions. 1000≤T≤1430 1.2≤ξ≤8, where T is the temperature of the powder mixture, ξ is the ratio of the specific flows FAr/FNH3, where FAr is the specific flow of the transport gas and FNH3 is the specific flow of the reactant gas. The ultrasonic treatment of BN nanoparticles agglomeration is realized followed by saturation of nanoparticles with antitumor drug by sorption and washing in distilled water.Linvention concerne des technologies nanomédicales, cest-à-dire la fabrication de nanosupports de médicaments pour une chimiothérapie antitumorale. Le résultat technique de linvention consiste à augmenter lefficacité de chimiothérapie antitumorale par augmentation de lactivité de labsorption de cellule de nanorécipients chargés avec un médicament antitumoral, éviter la toxicité de nanorécipient pour des cellules en raison de lutilisation de nanoparticules de nitrure de bore dispersées de 50-300 nm de diamètre avec une surface extérieure bien développée. Le résultat techn
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