БИШОФФ Александр (US),РАЙКАР Сандип Н. (IN),САММИТА Сирниваса Раджу (IN),ПРАБХУ Ганеш (IN),СУБРАМАНЬЯ Хосахалли (IN),СУНДАРЕСАН Кумар (IN)
申请号：
RU2010142936/04
公开号：
RU2010142936A
申请日:
2009.03.20
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. The compound of the formula:! ! where n is 1 or 2； ! R1 represents aryl, heterocycloalkyl, heteroaryl or heterocycle； ! R2 is aryl； ! each of R3 and R4 independently represents hydrogen, halogen or alkyl； or ! R3 and R4 together with the carbon atom to which they are attached form a cycloalkyl group； ! R5 represents hydrogen or alkyl； ! where if n is 1 or 2, then X represents —C (O) -； ! where an aryl, heteroaryl or heterocyclic group, if present, may optionally be substituted with one or more halogen, hydroxy, arylamino, amido, alkylamido, alkyl, halogenated alkyl, aryl, heteroaryl, heterocycle, alkoxy or aryloxy, and combinations thereof； ! or its pharmaceutically acceptable salts, solvates, hydrates or solvates of its pharmaceutically acceptable salts. ! 2. The compound according to claim 1, where n is 1, and R1 is aryl, heteroaryl or heterocycle. ! 3. The compound according to claim 1, where R2 is substituted by one or more alkyl, halogen or a halogenated alkyl group. ! 4. The compound according to claim 1, where R1 represents aryl. ! 5. The compound according to claim 4, where R1 is substituted by one or more aryl, heteroaryl or heterocycle. ! 6. The compound according to claim 1, where the compound is N-biphenyl-4-yl-3-oxo-3- [4- (2-trifluoromethyl-benzoyl) piperazin-1-yl] propionamide or its pharmaceutically acceptable salts . ! 7. The compound according to claim 1, where the compound is: N-biphenyl-4-yl-3- [4- (5-fluoro-2-trifluoromethyl-benzoyl) piperazin-1-yl] -3-oxo-propionamide or its pharmaceutically acceptable salts. ! 8. The compound according to claim 1, where the compound is: N-biphenyl-4-yl-3- [4- (2-methyl-benzoyl) piperazin-1-yl] -3-oxo-propionamide yl1. Соединение формулы: ! !где n равно 1 или 2； ! R1 представляет собой арил, гетероциклоалкил, гетероарил или гетероцикл； ! R2 представляет собой арил； ! каждый из R3 и R4 независимо представляет собой водород, галоген или алкил； или ! R3 и R4 вместе с атомом углерода, к которому они прис
