Bin Li,Zhiyuan Li,Fang Lin,Zhimei Gao,Zuojia Chen,Andy Tsun,Kongchen Li
申请号：
US15454487
公开号：
US20170189496A1
申请日:
2017.03.09
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A method for the treatment and/or the prevention of a disease or a symptom related to dysfunction of regulatory T cell immunomodulation includes administering to a subject in need thereof compositions that regulate regulatory T cell immunomodulatory function, in which the compositions may be prepared by contacting starting materials with phosphorylation pathway-related factors, the agonists or the antagonists thereof. The phosphorylation pathway-related factors are selected from: proto-oncogene protein PIM1 and the coding sequence thereof. The regulation is achieved by regulating the activity of regulators of regulatory T cells selected from the group: FOXP3, IL-2, GITR, CTLA4, and a combination thereof.
